Binciken serological na Ciwon Hannu, Ƙafa, da Baki

Ciwon Hannu, Ƙafa, da Baki (HFMD).

Ciwon Hannu, Ƙafa, da Baki yana da yawa a tsakanin ƙananan yara. Yana da saurin yaɗuwa, yana da adadi mai yawa na cututtukan asymptomatic, hadaddun hanyoyin watsawa, da saurin yaɗuwa, mai yuwuwar haifar da barkewar annoba cikin ɗan gajeren lokaci, yana mai da ƙalubalen shawo kan cutar. A lokacin barkewar cutar, cututtuka na gama-gari a makarantun kindergartens da cibiyoyin kula da yara, da kuma tari na iyalai na iya faruwa. A cikin 2008, Ma'aikatar Lafiya ta haɗa da HFMD a cikin kula da cututtuka masu yaduwa na Category C.

Coxsackievirus A16 (CA16) da Enterovirus 71 (EV71) ƙwayoyin cuta ne da ke haifar da HFMD. Bayanai na annoba sun nuna cewa CA16 yakan yi yawo a lokaci guda tare da EV71, wanda ke haifar da barkewar cutar HFMD akai-akai. A lokacin waɗannan barkewar, adadin cututtukan CA16 ya zarce na EV71, galibi yana lissafin sama da kashi 60% na jimillar cututtuka. HFMD da EV71 ke haifarwa zai iya haifar da lalacewar tsarin juyayi na tsakiya. Adadin lokuta masu tsanani da adadin mace-macen da ke tsakanin marasa lafiya da suka kamu da cutar ta EV71 ya fi girma fiye da waɗanda suka kamu da sauran ƙwayoyin cuta na enterovirus, tare da mummunan adadin masu mutuwa ya kai 10% -25%. Duk da haka, kamuwa da cutar CA16 gabaɗaya baya haifar da cututtuka daban-daban masu alaƙa da tsarin juyayi na tsakiya kamar su aseptic meningitis, ƙwaƙwalwar ƙwaƙwalwa mai kwakwalwa, da poliomyelitis-kamar inna. Don haka, ganewar asali na farko yana da mahimmanci musamman don ceton rayukan mutane masu tsanani.

Gwajin asibiti

Gwajin asibiti na yanzu don HFMD da farko ya haɗa da gano nucleic acid na ƙwayoyin cuta da gano ƙwayoyin rigakafin ƙwayoyin cuta. Kamfanin Beier yana amfani da enzyme-linked immunosorbent assay (ELISA) da kuma hanyoyin zinari na colloidal don haɓaka Enterovirus 71 Antibody Test Kits da Coxsackievirus A16 IgM Antibody Test Kits don gano bambanci na ƙwayoyin cuta na HFMD. Ganowar rigakafin ƙwayar cutar jini yana ba da hankali sosai, ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun bayanai, kuma yana da sauƙi, mai sauri, kuma ya dace da gwajin asibiti a cikin cibiyoyin kiwon lafiya a kowane matakai da kuma manyan binciken sa ido kan cutar.

Takamaiman Manufofin Ganewa da Muhimmancin Asibiti na Cutar EV71

Ƙayyadaddun ganewar asali na EV71 kamuwa da cuta ya dogara ne akan gano EV71-RNA, EV71-IgM, da EV71-IgG antibodies a cikin jini, ko gano EV71-RNA a cikin samfurori na swab.

Bayan kamuwa da cutar EV71, ƙwayoyin rigakafi na IgM sun fara bayyana a cikin mako na biyu. Magungunan rigakafi na IgG sun fara bayyana a cikin mako na biyu bayan kamuwa da cuta kuma suna dawwama na dogon lokaci. EV71-IgM muhimmiyar alama ce ta kamuwa da cuta ta farko ko ta kwanan nan, tana sauƙaƙe ganowa da wuri da kuma maganin kamuwa da cutar EV71. EV71-IgG mabuɗin alama ce don bambance-bambancen ganewar kamuwa da kamuwa da cuta, mai amfani ga binciken cututtukan cututtuka da kimanta ingancin rigakafin. Gano canji a cikin titer antibody tsakanin nau'i-nau'i mai tsanani da kuma convalescent samfurori na iya ƙayyade matsayin kamuwa da cuta na EV71; alal misali, karuwa mai ninki huɗu ko mafi girma na geometric a cikin titer antibody a cikin maganin convalescent idan aka kwatanta da m serum ana iya yin hukunci a matsayin kamuwa da cuta ta EV71 na yanzu.

Ƙayyadaddun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru na CA16

Ƙayyadaddun ganewar asali na CA16 kamuwa da cuta ya dogara ne akan gano CA16-RNA, CA16-IgM, da CA16-IgG antibodies a cikin jini, ko gano CA16-RNA a cikin samfurori na swab.

Bayan kamuwa da cutar CA16, ƙwayoyin rigakafi na IgM sun fara bayyana a cikin mako na biyu. Magungunan rigakafi na IgG sun fara bayyana a cikin mako na biyu bayan kamuwa da cuta kuma suna dawwama na dogon lokaci. CA16-IgM alama ce mai mahimmanci na kamuwa da cuta na farko ko kwanan nan.

Muhimmancin Haɗin EV71 da CA16 Gwajin Antibody

HFMD yana haifar da yawancin enteroviruses, tare da serotypes na yau da kullum shine EV71 da CA16. Bincike ya nuna cewa HFMD da ƙwayar cuta ta CA16 ke haifarwa yawanci tana ba da alamu na yau da kullun, yana da ƙarancin rikitarwa, da kyakkyawan tsinkaye. Sabanin haka, HFMD da EV71 ke haifarwa sau da yawa yana gabatar da ƙarin alamun cututtuka na asibiti, yana da mafi girman adadin lokuta masu tsanani da mutuwa, kuma akai-akai yana haɗuwa da rikice-rikice na tsarin juyayi na tsakiya. Alamomin asibiti na HFMD suna da rikitarwa kuma sau da yawa ba su da alaƙa, yin ganewar asibiti musamman ƙalubale, musamman a farkon matakan. Muhimmancin haɗakar gwajin rigakafin ƙwayar cuta ya ta'allaka ne cikin maye gurbin hanyoyin keɓewar ƙwayoyin cuta na al'ada masu cin lokaci da wahala, gano ƙwayoyin cuta ta hanyar serologically, da samar da tushen gano asibiti, dabarun jiyya, da hasashen cututtuka.

Binciken Ayyukan Samfur

Saukewa: EV71-IgMKitBinciken Ayyuka

Sakamako ya nuna:Kit ɗin gwajin Beier EV71-IgM yana nuna babban hankali da ƙayyadaddun ƙayyadaddun ƙayyadaddun gwajin jini daga masu kamuwa da EV71. Tushen bayanai: Cibiyar Kula da Cututtuka da Cututtuka ta Kasa, CDC ta kasar Sin.

EV71-IgG ELISA Binciken Ayyukan Aiki (I)

EV71-IgG ELISA Binciken Aiki (II)

Sakamako ya nuna:Kit ɗin gwajin Beier EV71-IgG yana nuna ƙimar ganowa mai yawa don maganin jini daga mutane masu kamuwa da cutar EV71 mai maimaitawa. Tushen bayanai: Cibiyar Kula da Cututtuka da Cututtuka ta Kasa, CDC ta kasar Sin.

CA16-IgM ELISA Binciken Ayyukan Aiki

Sakamako ya nuna:Kit ɗin Gwajin Beier CA16-IgM yana nuna ƙimar ganowa mai girma da kyakkyawar yarda. Tushen bayanai: Cibiyar Kula da Cututtuka da Cututtuka ta Kasa, CDC ta kasar Sin.

EV71-IgM Gwajin Gwajin (Colloidal Zinare) Binciken Ayyuka

Sakamako ya nuna:Kit ɗin Gwajin Beier EV71-IgM (Colloidal Gold) yana nuna haɓakar hankali da ƙayyadaddun ƙayyadaddun ƙayyadaddun gwajin jini daga masu kamuwa da EV71. Tushen bayanai: Cibiyar Kula da Cututtuka da Cututtuka ta Kasa, CDC ta kasar Sin.

Kayan Gwaji na CA16-IgM (Colloidal Zinare) Binciken Ayyuka

Sakamako ya nuna:Kayan Gwajin Beier CA16-IgM (Colloidal Gold) yana nuna babban hankali da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙwayar cuta daga masu kamuwa da CA16. Tushen bayanai: Cibiyar Kula da Cututtuka da Cututtuka ta Kasa, CDC ta kasar Sin.